Uwe Koedel Selected Research

Leukocytosis (Pleocytosis)

1/2018	Mast Cells Are Activated by Streptococcus pneumoniae In Vitro but Dispensable for the Host Defense Against Pneumococcal Central Nervous System Infection In Vivo.
11/2010	CXCL16 contributes to neutrophil recruitment to cerebrospinal fluid in pneumococcal meningitis.
10/2008	Innate immunity to pneumococcal infection of the central nervous system depends on toll-like receptor (TLR) 2 and TLR4.
10/2008	Myeloid Src kinases regulate phagocytosis and oxidative burst in pneumococcal meningitis by activating NADPH oxidase.
1/2007	Differential regulation of blood-brain barrier permeability in brain trauma and pneumococcal meningitis-role of Src kinases.
6/2004	MyD88 is required for mounting a robust host immune response to Streptococcus pneumoniae in the CNS.
8/2003	Lack of IL-6 augments inflammatory response but decreases vascular permeability in bacterial meningitis.
4/2003	CSF and serum levels of soluble fractalkine (CX3CL1) in inflammatory diseases of the nervous system.
11/2002	Role of the urokinase plasminogen activator system in patients with bacterial meningitis.

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Uwe Koedel Research Topics

Disease

28	Pneumococcal Meningitis (Streptococcus pneumoniae Meningitis) 07/2020 - 01/2002
27	Bacterial Meningitis 01/2022 - 01/2002
22	Meningitis 01/2021 - 01/2002
14	Infections 11/2017 - 10/2003
10	Inflammation (Inflammations) 01/2018 - 01/2002
9	Leukocytosis (Pleocytosis) 01/2018 - 11/2002
6	Pneumococcal Infections 10/2011 - 01/2003
5	Brain Injuries (Brain Injury) 07/2020 - 01/2007
4	Hearing Loss (Hearing Impairment) 10/2013 - 04/2003
3	Meningococcal Meningitis 07/2020 - 12/2014
3	Hemorrhage 04/2019 - 12/2014
3	Brain Edema (Cerebral Edema) 01/2007 - 01/2003
2	Disease Progression 01/2021 - 11/2011
2	Encephalitis (Encephalitis, Rasmussen) 04/2019 - 11/2011
2	Viral Meningitis 07/2005 - 04/2003
2	Intracranial Hemorrhages (Intracranial Hemorrhage) 01/2005 - 01/2003
2	Necrosis 06/2004 - 08/2003
2	Guillain-Barre Syndrome 04/2003 - 11/2002
1	Seizures (Absence Seizure) 01/2021
1	Fever (Fevers) 01/2021
1	Lymphoma (Lymphomas) 10/2019
1	Neoplasms (Cancer) 10/2019
1	Clinical Deterioration 04/2019
1	Gliosis 01/2019
1	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 12/2018
1	Lyme Disease (Disease, Lyme) 01/2017
1	Post-Lyme Disease Syndrome 08/2015
1	Cerebral Infarction 04/2014
1	Neurologic Manifestations (Neurological Manifestations) 10/2013
1	Body Weight (Weight, Body) 10/2013

Drug/Important Bio-Agent (IBA)

14	Anti-Bacterial Agents (Antibiotics)IBA 01/2021 - 12/2002
12	Proteins (Proteins, Gene)FDA Link 01/2019 - 03/2002
11	ChemokinesIBA 01/2014 - 11/2002
10	CytokinesIBA 01/2021 - 12/2002
5	Interleukin-6 (Interleukin 6)IBA 12/2018 - 01/2003
5	Toll-Like Receptors (Toll-Like Receptor)IBA 08/2012 - 04/2007
4	Dexamethasone (Maxidex)FDA LinkGeneric 01/2021 - 12/2002
4	Ceftriaxone (Ceftriaxon)FDA LinkGeneric 07/2020 - 10/2003
4	Pattern Recognition ReceptorsIBA 08/2012 - 01/2003
4	Interleukin-1beta (Interleukin 1 beta)IBA 09/2006 - 01/2002
4	Messenger RNA (mRNA)IBA 06/2004 - 03/2002
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 06/2004 - 01/2002
3	Matrix Metalloproteinases (MMPs)IBA 07/2020 - 08/2003
3	Plasminogen Activator Inhibitor 1IBA 04/2014 - 11/2002
3	AntibodiesIBA 01/2014 - 08/2003
3	Complement System Proteins (Complement)IBA 10/2011 - 06/2004
2	batimastat (BB 94)IBA 07/2020 - 12/2014
2	Biomarkers (Surrogate Marker)IBA 10/2019 - 12/2014
2	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 12/2018 - 08/2003
2	paquinimodIBA 11/2017 - 07/2015
2	InflammasomesIBA 01/2017 - 11/2011
2	Adenosine Triphosphate (ATP)IBA 01/2017 - 11/2011
2	Plasminogen Activators (Plasminogen Activator)IBA 04/2014 - 11/2002
2	AntioxidantsIBA 10/2013 - 10/2003
2	Acetylcysteine (Siran)FDA LinkGeneric 10/2013 - 12/2006
2	Toll-Like Receptor 2IBA 12/2009 - 01/2003
2	Complement Receptors (Complement Receptor)IBA 10/2008 - 01/2003
2	src-Family KinasesIBA 10/2008 - 01/2007
2	Transforming Growth Factor beta (TGF-beta)IBA 01/2007 - 09/2006
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2007 - 07/2005
2	NitrogenIBA 12/2006 - 09/2006
2	Urokinase Plasminogen Activator ReceptorsIBA 03/2005 - 11/2002
2	Macrophage Inflammatory Proteins (Macrophage Inflammatory Protein 1)IBA 06/2004 - 01/2003
2	Chemokine CX3CL1IBA 04/2003 - 02/2003
2	Oxidants (Oxidizing Agents)IBA 12/2002 - 12/2002
2	Peptide Hydrolases (Proteases)FDA Link 12/2002 - 12/2002
1	SteroidsIBA 01/2022
1	Bacterial DNAIBA 01/2021
1	Conjugate VaccinesIBA 01/2021
1	Pneumococcal Vaccines (Pneumococcal Polysaccharide Vaccine)IBA 01/2021
1	Matrix Metalloproteinase InhibitorsIBA 07/2020
1	Doxycycline (Periostat)FDA LinkGeneric 07/2020
1	Tetracycline (Achromycin)FDA LinkGeneric 07/2020
1	Neuroprotective AgentsIBA 07/2020
1	B-Cell Activating FactorIBA 10/2019
1	LigandsIBA 10/2019
1	Acyclovir (Aciclovir)FDA LinkGeneric 04/2019
1	ProteomeIBA 01/2019
1	OligopeptidesIBA 01/2019
1	Virulence Factors (Pathogenicity Factors)IBA 01/2019
1	Sialic AcidsIBA 01/2019
1	N-Acetylneuraminic Acid (Sialic Acid)IBA 01/2019
1	Cell Adhesion MoleculesIBA 01/2019
1	Cromolyn Sodium (Cromoglicic Acid)FDA LinkGeneric 01/2018
1	Daptomycin FDA Link 11/2017
1	Pathogen-Associated Molecular Pattern MoleculesIBA 11/2017
1	HMGB1 Protein (HMG1)IBA 11/2017
1	InterleukinsIBA 01/2017
1	VaccinesIBA 11/2016
1	Toll-Like Receptor 4IBA 07/2015
1	ethyl pyruvateIBA 06/2013
1	Phosphatidylinositol 3-Kinases (PI 3 Kinase)IBA 02/2013
1	Interleukin-1 (Interleukin 1)IBA 11/2011

Therapy/Procedure

22	Therapeutics 01/2021 - 01/2002
2	Critical Care (Surgical Intensive Care) 12/2006 - 01/2005
1	Contraindications 01/2021
1	Decompressive Craniectomy 04/2019
1	Complementary Therapies (Alternative Medicine) 01/2017
1	Aftercare (After-Treatment) 08/2015
1	Spinal Injections 07/2015